Humans

Tischer et al. (1995) found weak reactivity to PCV1 antigen in serum samples from healthy humans (116 tested, 20.07% positive), blood donors (175 tested, 8.6% positive), and hospitalized adult patients with fevers (188 tested, 23.9% positive) by IFA. In contrast, sera of 200 humans were found to be negative for PCV1-specific antibodies by IFA (Allan et al. 1994) and 120 randomly selected samples from healthy humans in Northern Ireland were found to be negative by IFA and ELISA for PCV2-specific antibodies (Allan et al., 2000). Ellis et al. (2000) tested serum from 54 swine veterinarians and 6 academic veterinarians and laboratory workers (involved in PCV2 research for several years) with a competitive PCV2 ELISA, a whole cell PCV2 ELISA, and a whole cell PCV1 ELISA. All samples were found to be negative for PCV2 and PCV1 specific antibodies (Ellis et al., 2000).

References:

Allan GM, McNeilly F, McNair I, Curran MD, Walker I, Ellis J, Konoby C, Kennedy S, Meehan B: Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Arch Virol. 145:853-857, 2000

Allan GM, Phenix KV, Todd D, McNulty MS: Some biological and physico-chemical properties of porcine circovirus. Zentralbl Veterinarmed B. 41:17-26, 1994

Ellis JA, Wiseman BM, Allan G, Konoby C, Krakowka S, Meehan BM, McNeilly F: Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada. J Am Vet Med Assoc. 217:1645-1646, 2000

Tischer I, Bode L, Apodaca J, Timm H, Peters D, Rasch R, Pociuli S, Gerike E: Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle. Arch Virol. 140:1427-1439, 1995