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Anumantha Kanthasamy, M.S., M.Phil., Ph.D. Dept. of Biomedical Sciences Professor & W.Eugene and Linda Lloyd Professor |
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| Research Interests / Areas of Expertise: Dr. Kanthasamy's work focuses on cellular and molecular mechanisms underlying Parkinson’s disease, Prion diseases and other related neurological disorders. Education & Certifications: M.S.: University of Madras, 1984. M.Phil.: University of Madras, 1985. Ph.D.: University of Madras, 1989. Teaching: General Pharmacology -- BMS 354/554 Advanced Vertebrate Physiology-I -- BMS 549 Advanced Vertebrate Physiology-II -- BMS 552 Special Topics in Anatomy, Physiology & Pharmacology -- BMS 590A-C Methods in Neuroscience- Lab course -- Neuro 557 General Principles in Toxicology -- Tox 501 Toxicology Methods -- Tox 502Cell Biology -- BMS 575X Selected Publications: Anantharam, V., Kitazawa, M., Wagner, J.W. Kaul, S and Kanthasamy, A.G. (2002), Caspase-3-dependent proteolytic cleavage of Protein Kinase C is essential for oxidative stress-mediated dopaminergic cell death following exposure to Methylcyclopentadienyl Manganese Tricarbonyl (MMT)., J. Neurosci., 22: 1738-1751. Kitazawa, M., Anantharam, V. and Kanthasamy, A.G. (2003), Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic activation of Protein Kinase Cd in dopaminergic cells: Relevance to oxidative stress and dopaminergic degeneration. Neuroscience, 119: 945-964. Kaul, S. Kanthasamy, A. Kitazawa, M., Anantharam, V. and Kanthasamy, A.G. (2003), Caspase-3-dependent proteolytic activation of Protein Kinase Cd mediates and regulates MPP+ induced apoptosis in dopaminergic cells: Relevance to oxidative stress and Parkinson’s disease. Eur. J. Neurosci., 18: 1387-1407. Kaul, S, Anantharam, V, Yang, Y, Choi, C, Kanthasamy, A and Kanthasamy, AG (2005) Tyrosine Phosphorylation Regulates the Proteolytic Activation of PKCd In Dopaminergic Neuronal Cells. J. Biol. Chem. 280: 28721-30. Kaul, S, Anantharam, V, Kanthasamy, A and Kanthasamy, AG (2005) Wild-type a-synuclein interacts with pro-apoptotic proteins PKCd and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Molecular Brain Research 139:137-52. Sun, F., Anantharam, V., Latchoumycandane, C., Kitazawa, M., Yang, Y., Kanthasamy, A. and Kanthasamy, AG. (2005) Dieldrin Induces Ubiquitin-Proteasome Dysfunction in α-Synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death. J. Pharmacol. Expt. Therapeutics 315:69-79. Choi, C. Kanthasamy, A., Anantharam, V, and Kanthasamy, A.G. (2006), Interaction of metals with prion protein: Possible role of divalent cations in the pathogenesis of prion diseases, Neurotoxicology, (in press).More... Complete Publications Back to Top Leadership: Chair, Interdepartmental Toxicology Graduate Program, Iowa State University, 2003- present Director, Parkinson’s Disorder Research Program, Dept. of Biomedical Sciences, Iowa State University, 1999- present Member, CSR-NIH Study Section, Neurotoxicology and Alcohol (NAL) , 2004-2008. Founding Member, Iowa Center for Advanced Neurotoxicology (ICAN). Consulting/counseling many Iowa farmers and others with Parkinson's disease. 2001-present. Grant Reviewer, NIH-NINDS & Michael J. Fox Foundation Study section, RFA-NS-02-006, Fast Track Grants for Parkinson's Disease Research, 2001. Research Advisory Council Member, College of Veterinary Medicine, Iowa State University, 2000-2003 Chair, 2nd and 3rd International Conferences on Antioxidants & Free Radicals in Health and Disease, Vancouver, B.C. Adhoc member, NIH-SBIR/STTR grant review panel, 1998.Advisory Member, Biotechnology Research Council, Iowa State University, 2005- present. Journal Reviewer: Journal Neuroscience, New England Journal of Medicine, Journal of Pharmacology and Experimental Therapeutics, Journal of Neurochemistry, FASEB Journal, Free Radical Biology and Medicine, Stroke, Brain Research, Journal of Neuroscience Research, Toxicology and Applied Pharmacology, Neurotoxicology, Neurotoxicity Research, Neurochemistry International, American College of Nutrition, Oncogene, Toxicology Sciences, and many other journals Honors & Awards: Named W.Eugene and Linda R. Endowed Professor, October 2005 Young Scientist Award, Association of Scientists of Indian Origin in America, Neuroscience Division. Member, CSR-NIH Study Section, Neurotoxicology and Alcohol (NAL) , 2004-2008. Best Research Paper Awards, European Society for Clinical Neuropharmacology Annual Meeting, Rome, Italy, 1996, International Neurotoxicology meeting, Arkansas, 2003.Young Investigator Award, American Society of Pharmacology and Experimental Therapeutics, 1992. Memberships: Society for Neuroscience Society of Toxicology International Society for Neurochemistry Experimental Biology-American Society for Experimental Therapeutics The New York Academy of Sciences The Iowa Academy of Sciences American Association for the Advancement of Science |