Research Interests / Areas of Expertise:
Research centers around the cellular and molecular mechanisms of neurodegeneration and application of such information to the development of novel strategies for treating Parkinson’s. Prion and other neurodenerative diseases. Currently, conducting research to examine the role of oxidative stress and ER stress in the etiopathogenesis of Parkinson’s disease (PD) and Prion diseases. 

Education & Certifications:
Post-Doc: Molecular Biophysics, Indian Institute of Science, India, 1987-1990.
Ph.D.: Molecular Biophysics, Indian Institute of Science, India, 1987.
M.S.: Biochemistry, Bangalore University, India, 1982.
B.S.: Chemistry, Bangalore University, India, 1980.


Teaching:
1. Neuro/GDCB/BMS 556: Cellular, Molecular and Developmental Neuroscience,
2. BMS575x: Cell Biology
3. Neuro 557: Advanced Neuroscience Techniques

Current and Past Memberships in Professional Societies
Society for Neuroscience
American Society for Cell Biology
International Brain Research organization
Society for Toxicology
Society for Toxicology, Central Midwest Chapter
American Society for Transplantation

Selected Publications:

Kanthasamy, A.G., Anantharam, V., Zhang, D.,  Latchoumycandane, C.,  Jin, H, Kaul, S and Kanthasamy, A. (2006), A Novel Peptide Inhibitor Targeted to Caspase-3 Cleavage Site of a Proapoptotic Kinase PKCdelta (PKCd) Protects against Dopaminergic Neuronal Degeneration in Parkinson’s disease Models. Free Radical Biology and Medicine, In press.

Sun F, Anantharam V, Zhang D, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. (2006), Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology. 27(5):807-15.

Choi CJ, Kanthasamy A, Anantharam V, Kanthasamy AG. (2006),     Interaction of metals with prion protein: Possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology.27(5):777-87.

Kanthasamy, AG., Kitazawa, M., Kanthasamy, A and Anantharam, V. (2005). Dieldrin-Induced Neurotoxicity: Relevance to Parkinson's Disease Pathogenesis. Neurotoxicology, 26, 701-19.

Kaul, S,  Anantharam, V, Kanthasamy, A and Kanthasamy, AG (2005) Wild-type a-synuclein interacts with pro-apoptotic proteins PKCd and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.  Molecular Brain Research 139:137-52.

Sun, F., Anantharam, V., Latchoumycandane, C., Kitazawa, M., Yang, Y., Kanthasamy, A. and Kanthasamy, AG. (2005) Dieldrin Induces Ubiquitin-Proteasome Dysfunction in α-Synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death.  J. Pharmacol. Expt. Therapeutics 315:69-79.

Kaul, S, Anantharam, V, Yang, Y, Choi, C, Kanthasamy, A and Kanthasamy, AG (2005) Tyrosine Phosphorylation Regulates the Proteolytic Activation of PKCd In Dopaminergic Neuronal Cells.  J. Biol. Chem. 280: 28721-30.

Kitazawa, M., Anantharam, V., Yang. Y., Hirata, Y., Kanthasamy, A and Kanthasamy, AG. (2005) Activation of protein kinase Cd by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochemical Pharmacol. 69:133-46.

Latchoumycandane, C., Anantharam, V., Kitazawa, M., Yang, Y., Kanthasamy, A. and Kanthasamy, AG. (2005) Protein Kinase C Delta (PKCd) is a Key Downstream Mediator of Manganese-induced Apoptosis in Dopaminergic  Clonal Cells. J. Pharmacol. Expt. Therapeutics.  313:46-45.

Anantharam, V., Kitazawa, M., Latchoumycandane, C., Kanthasamy, A. and Kanthasamy, AG. (2005) Blockade of PKCd Proteolytic Activation by Loss of Function Mutants Rescue Mesencephalic Dopaminergic Neurons from Methylcyclopentadienyl Manganese Tricarbonyl (MMT)-induced Apoptotic Cell Death. Ann. N.Y. Acad. Sci., 1035:271-289.

Full CV     Back to Top