Research Interests / Areas of Expertise:
General area of interest is immunology of infectious diseases of cattle and swine. Specific interest in suppression of immune function, neutrophil function, vaccine development and evaluation. Current projects on bovine viral diarrhea virus, bovine respiratory syncitial virus, and nipah virus.


Education & Certifications:
D.V.M.: Iowa State University, 1975.
M.S.: Iowa State University, 1979.
Ph.D.: Iowa State University, 1981.
Diplomate: American College of Veterinary Microbiologists, 1982.
Clarence Hartley Couvalt Distinguished Professor: Iowa State University, 1995.


Teaching:
Veterinary Immunology -- VMPM 380


Selected Publications:
Charerntantanakul, W., R. Platt, W. Johnson, M. Roof, E. Vaughn, J. A. Roth. 2006. Immune responses and protection by vaccine and various vaccine adjuvant candidates to virulent porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol, 109:99-115.

Palic, D., C.B. Andreasen, D.M. Herolt, B.W. Menzel, J.A. Roth. 2006. Immunomodulatory Effects of β-glucan on neutrophil function in fathead minnows (Pimephales promelas Rafinesque, 1820). Dev Comp Immunol, 30:817-830.

Palic, D., D.M. Herolt, C.B. Andreasen, B.W. Menzel, J.A. Roth. 2006.  Anesthetic efficacy of tricaine methanesulphonate, metomidate and eugenol: Effects on plasma cortisol concentration and neutrophil function in fathead minnow (Pimephales promelas Rafinesque, 1820). Aquaculture, 254(1-4):675-685.

Platt, R., W. Burdett, J.A. Roth. 2006. Induction of antigen specific T cell subset activation to bovine respiratory disease viruses by a modified-live virus vaccine. Am J Vet Res, 67(7):1179-1184.

Weingartl, H.M., Y. Berhane, J.L. Caswell, S. Loosmore, J.C. Audonnet, J.A. Roth, M. Czub. 2006.  Recombinant Nipah virus vaccines protect pigs against challenge. J Virol, 80(16):7929-7938.

Charerntantanakul, W., R. Platt, J.A. Roth. 2006. Effects of porcine reproductive and respiratory syndrome virus-infected antigen presenting cells on T cell activation and antiviral cytokine production. Viral Immunol, 19(4):646-661.

Niang, M., M. Diallo, O. Cisse, M. Kone, M. Doucoure, J.A. Roth, V. Balcer-Rodrigues, L. Dedieu. 2006. Pulmonary and serum antibody responses elicited in zebu cattle experimentally infected with Mycoplasma Mycoides subsp. mycoides SC by contact exposure. Vet Res, 37:733-744.

Platt, R., J.A. Roth, R.L. Royer, C.O. Thoen. 2006. Monitoring responses by use of 5-color flow cytometry in subsets of peripheral T cells obtained from cattle inoculated with a killed Mycobacterium avium subspecies paratuberculosis vaccine. Am J Vet Res, 67(12):2050-2058.

 Palic, D., C.B. Andreasen, J. Ostoji?, R. M. Tell, J.A. Roth. 2006. Zebrafish (Danio rerio) whole kidney assays to measure neutrophil extracellular trap release and degranulation of primary granules. J Immunol Methods, Accepted for Publication.

 Palic, D., J. Ostoji?, C.B. Andreasen, J.A. Roth. 2006. Fish cast NETs: Neutrophil extracellular traps are released from fish neutrophils. Dev Comp Immunol, Accepted for Publication.

 Paul, M.A., L.E. Carmichael, H. Childers, S. Cotter, A. Davidson, R. Ford, K.F. Hurley, J.A. Roth, R.D. Schultz, E. Thacker, L. Welborn. 2006. 2006 AAHA canine vaccine guidelines. J Am Anim Hosp Assoc, 42:80-89.

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Federal Advisory Panels:
Interagency Weapons of Mass Destruction (WMD) Counter Measures Working Group – Animal Pathogens Research and Development Subgroup (2003-2004)

White House Office of Science and Technology Policy (OSTP) Agroterrorism Countermeasures Blue Ribbon Panel (Dec 2003 - March 2004), (Chair, Immunotherapeutics Working Group)

National Science Advisory Board for Biosecurity (NSABB) (2005-2008)


Leadership:
Director, Center for Food Security and Public Health.

Executive Director, Institute for International Cooperation in Animal Biologics (IICAB).

Councilor, Society for Tropical Veterinary Medicine, 2001-2005.

President, American College of Veterinary Microbiologists, 2004-2008.

Past President, American Association of Veterinary Immunologists.

Veterinary Scientific Conference Committee, International Association of Biologicals

Honors & Awards:
AVMA Public Service Award, 2006

ISU Student Chapter of the AVMA, Basic Science Teaching Award, 1991, 1997, 2001.

AVMA 12^th International Veterinary Congress Prize, 2001.

John G. Salsbury Endowed Chair in Veterinary Medicine, 1998-2001.

Distinguished Veterinary Immunologist Award, American Association of Veterinary Immunologists, 1997.

Clarence Hartley Couvalt Distinguished Professor, 1995.

ISU Foundation Award for Mid-Career Achievement in Research, 1994.

Faculty Citation, 1993.

Beecham Award for Research Excellence, 1986.

Outstanding Young Alumnus, 1985.

Norden Distinguished Teacher Award, 1983 and 1993.


Memberships:
American Veterinary Medical Association
American Society for Microbiology
American Association of Veterinary Immunologists
American Association of Swine Veterinarians
American Association of Bovine Practitioners
Conference of Research Workers in Animal Disease
Iowa Veterinary Medical Association
US Animal Health Association
American College of Veterinary Microbiologists
Society for Tropical Veterinary Medicine
International Association for Biologicals