Research Interests / Areas of Expertise:
Our research focuses on bacterial diseases of production animals, including their effects on animal health, public health and food safety. The long-term goal of one of our projects is to establish the molecular basis of virulence and antimicrobial resistance of avian Pathogenic Escherichia coli (APEC), the causative agent of colibacillosis, an economically devastating problem for the poultry industry. Establishing the molecular basis of APEC virulence and resistance should lead to more rational approaches for future colibacillosis control strategies.

Education & Certifications:
D.V.M.: University of Georgia, Athens, GA, 1988.
M.S.: Medical Microbiology, University of Georgia, Athens, GA, 1989.
Ph.D.: Medical Microbiology, University of Georgia, Athens, GA, 1992.

Selected Publications:
Nolan, L.K., Horne, S.M., Giddings, C.W., Foley, S.L., Johnson, T.J., Lynne, A.M., and Skyberg, J. 2003. Serum Complement Resistance, iss, and Virulence of Avian Escherichia coli. Vet Res Comm. 27: 101-110.

*Tibbetts, R.J., White, D.G., Dyer, N.W., Giddings, C.W., and Nolan, L.K. 2003. Characterization of Escherichia coli Isolates Incriminated in Mink Colisepticemia. Vet Res Comm. 27: 341-357.

*Foley, S.L., Horne, S.M., Giddings, C.W., Gustad, T.R., Robinson, M., and Nolan, L.K. 2003. Monoclonal Antibodies to Avian Escherichia coli Iss. Avian Dis. 47: 79-86.

Gibbs, P.S., Maurer, J.J., Nolan, L.K., and Wooley, R.E. 2003. Prediction of Chicken Embryo Lethality with the Avian Escherichia coli Traits Complement Resistance, Colicin V Production, and Presence of the Increased Serum Survival Gene Cluster (iss). Avian Dis. 47:370-379.

*Skyberg, J.A, Horne, S.M., Giddings, C.W., Wooley, R.E., Gibbs, P.S., and Nolan, L.K. 2003. Characterizing Avian Escherichia coli Isolates with Multiplex PCR. Avian Dis. 47:1441-1447.

*Horne, S.M., Goplin, J., and Nolan, L.K. 2004. Cloning and Sequence Analysis of cnf-1 from Virulent Bovine and Mink Escherichia coli Isolates. Vet Res Comm. 28:103-112.

*Johnson, T.J., Skyberg, J., and Nolan, L.K. 2004. Multiple Antimicrobial Resistance Region of a Putative Virulence Plasmid from an Escherichia coli Isolate Incriminated in Avian Colibacillosis. Avian Dis. 48: 351-360.

Balasubramanian,S., Panigrahi, S., Logue, C., Marchello, M., Doetkott, C., Gu, H., and Nolan, L.K. 2004. Spoilage Identification of Beef Using an Electronic Nose System. Trans Am Soc Agric Eng 47: xxx-xxx.

*Rodriguiz-Siek, K.E., Giddings, C.W., Fakhr, M., Doetkott, C., Johnson, T.J., and Nolan, L.K. 2004. Defining an APEC Pathotype. Accepted with revisions by Vet Res. (9/04)

Johnson, T.J., Siek, K., Skyberg, J., Doetkott, C., and Nolan, L.K. Plasmid-Linked Virulence among Avian Pathogenic Escherichia coli. As part of the Proceedings of the Biannual Meeting of the International Plasmid Biology Society, Corfu, Greece, September 2004. Accepted by Plasmid (10/05)

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Leadership:

• Executive Chair, College of Veterinary Medicine, Iowa State University, Ames, Iowa, 2006-
• Chair, Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, 2003-
• Interim Chair, Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 2004-2005.
• Director, Great Plains Institute of Food Safety, North Dakota State, 1999-2003
• Member, Wellness Center Advisory Board, NDSU, 2001-2003
• Member, North Dakota EPSCoR Steering Committee, 2001-2002
• Member, Center for Advanced Technology Transfer and Traineeships Advisory Board, NDSU, 2002-2003
• Member, NDSU Research Foundation Advisory Board, 2002-2003
• Ad hoc Reviewer, USDA NRICG Program, 1993, 1994, 2000, 2001, 2002
• Member, Board of Scientific Reviewers, American Journal of Veterinary Research, 1994 1996
• Ad hoc Reviewer, Journal of American Veterinary Medical Association, 1994, 1995, 1997, 1998, 2001
• Ad hoc Reviewer, Plant Disease, 1996, 1997
• Ad hoc Reviewer, Veterinary Research Communications, 1997, 1999, 2000, 2001
• Member, USDA Challenge Grants Review Panel, USDA-HEP Program, Washington, D.C., 1998
• Ad hoc Reviewer, American Journal of Veterinary Research, 1999, 2000
• Member, Program Committee, National Alliance for Food Safety, 1st Annual Meeting, Washington, D.C., 1999
• Chair, Food and Environmental Safety Session, Conference of Research Workers in Animal Disease, Chicago, IL, 1999, 2000 (Co-Chair in 2001)
• Member, Editorial Review Board, Animal Health Research Reviews, 1999-2000
• Member, FDA Food Animal Grants Review Panel (Microbiological Hazards Associated with the Food Animal Production Environment), CVM-FDA, Rockville, MD, 2000
• Section Editor, Food and Environmental Safety Section, Animal Health Research Reviews, 2000-
• Member, FDA-CVM's Veterinary Medicine Advisory Committee, 2003-2006

Honors & Awards:

• Preferred AG Instructor, College of Agriculture Student Activities Council, NDSU, 1995
• Mortar Board Preferred Professor, NDSU, 1996, 1997, 1998, 1999
• Commendation, College of Agriculture Excellence in Teaching, Early Career, NDSU, 1996
• Member, Phi Kappa Phi, 1998-
• Mary McCannel Gunkelman 10th Annual Recognition Award, NDSU, 1998
• University-Wide Odney Teaching Award, NDSU, 1999
• Outstanding Academic Advisor, College of Agriculture, Mortar Board
• National Honor Society, NDSU, 1999
• Professorship, Walter F. and Verna Gehrts Presidential Professor, NDSU, 2001-2003
• Distinguished Educator of the Year, Blue Key National Honor Society, NDSU, 2001

Memberships:
American Veterinary Medical Association, 1984-
American Association of Avian Pathologists, 1991-
American Society for Microbiology, 1992-
Research Workers in Animal Disease, 1993-
International Society of Plasmid Biology, 2004-

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