M. Heather West Greenlee, Ph.D.
Dept. of Biomedical Sciences
Assistant Professor

   
Phone: (515) 294-9251
Fax: (515) 294-2315
E-mail: mheather@iastate.edu
Address:
2070 Veterinary Medicine
Iowa State University
Ames, IA 50011-1250
USA

 

Research Interests / Areas of Expertise:
Dr. Greenlee's research focuses on the molecular basis of neural differentiation. Current projects include:
  • The effect of the Alzheimer's protein, beta-amyloid on neural stem cell differentiation.
  • The developmental proteome of retinal progenetor cells.
  • The importance of vesicle trafficking protein, SNAP-25 for photoreceptor differentiation and development.

Education & Certifications:
Ph.D.: Iowa State University, 1999.

Teaching:
BMS 350 - Comparative Veterinary Physiology
Neuro 557- Advanced Neuroscience Techniques

Selected Publications:
Uemura, E. and M. H. West Greenlee. (2001) Amyloid ß-peptide prevents exocytosis and inhibits neuronal glucose uptake. J Exp Neurol. 170: 270-276

M. H. West Greenlee, C. B. Roosevelt and D. S. Sakaguchi. (2001) Differential localization of SNARE complex proteins SNAP-25, Syntaxin and Synaptobrevin during development of the mammalian retina. J. Comp Neurol., 430 306-320.

T. Prapong, J. Buss, W. Hsu, P. Heine, M.H. Greenlee, E. Uemura. (2001) Amyloid beta-peptide decreases neuronal glucose uptake despite causing increase in GLUT3 mRNA transcription and GLUT3 translocation to the plasma membrane. J. Exp. Neurol. 174: 253-258

M. H. West Greenlee, M.C. Wilson, D.S. Sakaguchi. (2002) Expression of SNAP-25 during mammalian retinal development: Thinking outside the synapse. In: Seminars in Cell and Developmental Biology: Membrane Trafficking, Secretion and Development: 13:99-106.

M. H. West Greenlee, E. Uemura, S.L. Carpenter, R.I. Doyle, J.E. Buss. (2003) Glucose uptake in PC12 cells: GLUT3 vesicle trafficking and fusion. J. Neuroscience Res. (in press)

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Honors & Awards:
Signal Transduction Training Group (STTG) Research Fellowship, 1995-98.
Premium for Academic Excellence (PACE) award recipient, 1994.


Memberships:
Society for Neuroscience
Association for Research in Vision and Ophthalmology