Research Interests / Areas of Expertise:
Dr. Wannemuehler investigates the interactions between host and bacterial pathogens with regards to mucosal immunity and inflammatory diseases of the bowel. He is particularly interested in the role normal flora has on development of mucosal immunity and mechanisms of antigen-specific T cell responses to regulate inflammation.


Education & Certifications:
M.S.: Idaho State University, 1980.
Ph.D.: University of Louisville, 1981.
PostDoc. Fellow: University of Alabama in Birmingham, 1980-83.


Teaching:
Advanced Cellular Immunology

Medical Immunology I - VMPM 520

Molecular Immunology - VMPM/BBMB 615

Participate in the Undergraduate Honors Research Program and Immunobiology Laboratory Rotations for first graduate students.

Participate in the Immunobiology Journal Club.


Selected Publications:
Hsu, T., D.L. Hutto, F.C. Minion, R.L. Zuerner, and M.J. Wannemuehler. 2001. Cloning of the β-hemolysin gene of Brachyspira (Serpulina) hyodysenteriae and analysis of the recombinant gene product. Infect. Immun. 69:706-711.

Bassaganya-Riera, J.R. Hontecillas-Magarzo, D.R. Zimmerman, and M.J. Wannemuehler. 2002. Long term influence of lipid nutrition on induction of CD8⁺ responses to viral or bacterial antigens. Vaccine 20:1435-1444.

Waters, W.R., K.R. Harkins, and M.J. Wannemuehler. 2002. Five color flow cytometric analysis of swine lymphocytes for detection of proliferaction, apoptosis, viability and phenotype. Cytometry 48:146-152.

Hontecillas, R., M.J. Wannemuehler, D.R. Zimmerman, D.L. Hutto, J.H. Wilson, D.U. Ahn, and J. Bassaganya-Riera. 2002. Nutritional regulation of bacterial-induced colitis by conjugated linoleic acid. J. Nutrition 132:2019-2027.

Minion, F.C., S.A. Menon, G.G. Maharias, and M.J. Wannemuehler. 2003. Enhanced murine antigen-specific type 1 responses using mycobacterial ESAT-6 sequences in DNA vaccines. Infect. Immun. 71:2239-2243.

Trott, D.J., M.R. Moeller, R.L. Zuerner, J.P. Goff, W.R. Waters, D.P. Alt, R.L. Walker, and M.J. Wannemuehler. 2003. Characterization of Treponema-phagedenis-like spirochetes isolated from papillomatous digital dermatitis lesion in dairy cattle. J. Clin. Microbiol. 41:2522-2529.


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Leadership:
Chairman, NC-62 Technical Committee for Swine Enteric Diseases, 10/89 to 10/91.

Secretary, NC-62 Technical Committee for Swine Enteric Diseases, 10/87 to 10/89.

Ad hoc reviewer of manuscripts submitted to Infection and Immunity and the Journal of Clinical Microbiology, 1989 - present.

Ad hoc reviewer of USDA Competitive Grants, 1988 - present.

Member, Editorial Board of Infection and Immunity, 1995-1997.

Chair, Institutional Animal Care and Use Committee

Member, Iowa State University Research Compliance Advisory Committee


Honors & Awards:
Pfizer Animal Health Award for Research Excellence, ISU, 1998.
Outstanding Immunobiology Faculty Member, 1992.
Honorary Member of Phi Zeta, 1992.
Post-doctoral Trainee, NAIAD grant No. A1 07051-06, 10/1980 to 9/1983.
Graduate Research Grant, University of Louisville, 1979.
Sigma Xi Research Grant, University of Louisville, 1978.


Memberships:
American Society for Microbiology
Conference of Research Workers in Animal Disease
Honorary Member of Phi Zeta