Vaclav (Wenzel) Ourednik, Ph.D.
Dept. of Biomedical Sciences
Associate Professor
   

Phone: (515) 294-3719
Fax: (515) 294-2315
E-mail: voured@iastate.edu
Address:
2048 College of Veterinary Medicine
Iowa State University
Ames, Iowa 50011-1250
USA
 

Research Interests / Areas of Expertise:
  • Genetic mechanisms underlying in vitro and in vivo differentiation of neural progenitors.
  • Possibilities how to harness the multipotent character of neural stem cells in the development of new therapeutic approaches to neurodegenerative diseases.
  • Graft/host interactions after neural transplantation leading to induction of regenerative processes in the host.


    Education & Certifications:
    M.S.: University of Berne, Switzerland, 1985.
    Ph.D.: University of Lausanne, Switzerland, 1993.

    Postdoctoral Training and Scholarships:
     1994-1995: Dalhousie University, Halifax, Canada
    1995-1998: Swiss Federal Institute of Technology, Zurich, Switzerland
    1998-2002: Harvard University, Boston, MA

    Selected Publications:
    Ourednik J*, Ourednik V*, Lynch WP, Snyder EY, & Schachner M., Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons: evidence in aged mice, Nat Biotech, 2002, accepted.

    Ourednik J, Ourednik V & Snyder EY, Neural tissue and stem cell grafts induce regenerative plasticity in damaged mammalian brain, Clin Neurosci Res, 2002; 2:80-85.

    Ourednik J, Ourednik V, Bastmeyer M, & Schachner M., Ectopic expression of the neural cell adhesion molecule L1 in astrocytes leads to changes in the development of the corticospinal tract, Eur J Neurosci 2001; 14:1464-1474.

    Ourednik V*, Ourednik J*, Flax J, Zawada M, Hutt C, Yang CL, Park KI, Kim SU, Sidman RL, Freed CR & Snyder EY, Segregation of human neural stem cells in the developing primate forebrain, Science 2001; 293:1820-1824.

    Ourednik V, Ourednik J, Park KI & Snyder EY, Neural stem cells - a versatile tool for cell replacement and gene therapy in the central nervous system, Clin Genet 1999; 56:267-278.

    * co-first authorship

    More...     Full CV     Back to Top


    Leadership:
    Symposia Cycle "Growth Factors & Signal Transduction", Iowa State University, 2002-2003


    Honors & Awards:
    Young Investigator Grant Award presented by the Parkinson's Action Network and Michael J. Fox, Clearwater, FL, 2000.

    Sharing of Pfizer Prize in Neurosciences (collaborative work between teams in Lausanne and Halifax), Zuerich, Switzerland, 1998.

    Award of the Killam Postdoctoral Fellowship from Dalhousie University, Halifax, Canada, 1994.


    Memberships:
    American Society for Neuroscience
    American Society for Neural Transplantation & Repair