Jinoh Kim

Education & Certifications  
  • Ph.D., Biochemistry, 2000, University of Connecticut, Storrs, CT
  • M.S., Molecular Biology, 1992, Seoul National University, Seoul, Korea
  • B.S., Zoology, 1990, Seoul National University, Seoul, Korea
  • 2017-Present: BMS 575
Research Focus & Interests  
  • Protein secretion/trafficking
  • Transport vesicles
  • Endoplasmic reticulum
  • Coat Protein Complex II (COPII)
  • Craniofacial diseases
  • Musculoskeletal diseases

Secretory proteins and transmembrane proteins are synthesized in the endoplasmic reticulum (ER). The vast majority of these proteins exit the ER via transport vesicles generated by coat protein complex II (COPII). Proper assembly of these COPII vesicles is essential for cell viability and animal development. My laboratory studies how various cargo molecules are packaged into COPII vesicles and what are the consequences of aberrant COPII vesicle assembly in human.

Honors & Awards  
  • Academic Senate Faculty Research Award, University of California-Davis, 2009 – 2010
  • Health System Research Award, University of California-Davis, 2008 – 2010
  • Graduate Student and Postdoctoral Scholar Welfare Committee, 2016-2017
  • UC Davis Medical School Admissions Committee, 2009-2017
  • American Society for Cell Biology, 2005-Present
Selected Publications  

NCBI Library

Peer reviewed: 20 selected publications.

1. Justice, C.M.*, J. Kim*, S.D. Kim, G. Yagnik, B. Carrington, R. Sood, A.F. Wilson and S.A. Boyadjiev. *Co-first author. 2017. A non-coding variant near BMP2 associated with sagittal non-syndromic craniosynostosis causes differential GFP expression in zebrafish, submitted.

2. Cloutier, M., C. Gauthier, J.-S. Fortin, L. Genève, K. Kim, S. Grunheid, J. Kim and J. Thibodeau. 2015. ER egress of invariant chain isoform p35 requires direct binding to MHCII molecules and is inhibited by the NleA virulence factor of enterohaemorragic Escherichia coli. Hum.Immunol. 76:292-296.

3. Garbes, L., K. Kim, A. Rieß, H. Hoyer-Kuhn,F. Beleggia, A. Bevot, M.J. Kim, Y.H. Huh, H.-S. Kweon, R. Savarirayan, D. Amor, P.M. Kakadia, K.O. Kagan, J. Becker, S.A. Boyadjiev, S. Bohlander, O. Semler, B. Wollnik, O. Semler, S. Bohlander, J. Kim* and C. Netzer*. *Co-corresponding author. 2015. Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta. Am.J.Hum.Genet. 96:432-439.

4. Weaver, K.N., M.E.I. Hallek, R.J. Hopkin, K.L. Sund, M. Henrickson, D. del Gaudio, A. Yuksel, G.O. Acar, M.B. Bober, J. Kim and S.A. Boyadjiev. 2014. Keutel syndrome: Report of two nobel MGP mutations and discussion of clinical overlap with arylsulfatase E deficiency and relapsing polychondritis. Am. J. Med. Genet. A. 164:1062-1068.

5. Kim, S.D., G. Yagnik, M. Cunningham, J. Kim, and S.A. Boyadjiev. 2014. MAPK/ERK signaling pathway analysis in primary osteoblasts from patients with non-syndromic sagittal craniosynostosis. Cleft Palate Craniofac J. 51:115-119.

6. Thanabalasuriar, A., J. Kim, and S. Gruenheid. 2013. The inhibition of COPII trafficking is important for intestinal epithelial tight junction disruption during enteropathogenic Escherichia coli and Citrobacter rodentium infection. Microbes Infect. 15:738-744.

7. Justice C.M., G. Yagnik, Y. Kim, I. Peter, E.W. Jabs, M. Erazo, X. Ye, L. Shi, M.L. Cunningham, V. Kimonis, T. Roscioli, S.A. Wall, A.O.M. Wilkie, J. Stoler, J.T. Richtsmeier, Y. Heuzé, P.A. Sanchez-Lara, M.F. Buckley, C.M. Druschel, J.L. Mills, M. Caggana, P.A. Romitti, D.M. Kay, C. Sanders, P.J. Taub, O.D. Klein, J. Boggan, M. Zwienenberg-Lee, C. Naydenov, J. Kim, A.F. Wilson, and S.A. Boyadjiev. 2012. A genome-wide association study identifies susceptibility loci for non-syndromic sagittal craniosynostosis near BMP2 and within BBS9. Nat. Genet. 44:1360-1364.

8. Yagnik, G., A. Ghuman, S.D. Kim, C.G. Stevens, V. Kimonis, J. Stoler, P. Sanchez-Lara, J. Bernstein, C. Naydenov, H. Drissi, M.L. Cunningham, J. Kim, and S.A. Boyadjiev. 2012. ALX4 gain-of-function mutations in non-syndromic craniosynostosis. Hum. Mut. 33:1626-1629.

9. Kim S.D., J.L. Liu, T. Roscioli, M.F. Buckley, G. Yagnik, S.A. Boyadjiev, and J. Kim. 2012. Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Lett. 586:1516-1521.

10. Thanabalasuriar, A., J. Bergeron, A. Gillingham, M. Mimee, J.L. Thomassin, N. Strynadka, J. Kim, and S. Gruenheid. 2012. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cell. Microbiol.14:1206-1218.

11. Kim, S.D., K.B. Pahuja, M. Ravazzola, J. Yoon, S.A. Boyadjiev, S. Hamamoto, R. Schekman, L. Orci, and J. Kim. 2012. The SEC23-SEC31 interface plays a critical role for export of procollagen from the endoplasmic reticulum. J. Biol. Chem. 287:10134-10144.

12. Fromme, J.C. and J. Kim. 2012. A rapid and quantitative coat protein complex II vesicle formation assay using luciferase reporters. Anal. Biochem. 421:482-488.

13. Zhang, B., C. Zheng, M. Zhu, J. Tao, M. Vasievich, A. Baines, J. Kim, R. Schekman, R.J. Kaufman, and D. Ginsburg. 2011. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of a1-antitrypsin. Blood 118:3384-3391.

14. Boyadjiev S.A., S.D. Kim, A. Hata, C. Haldeman-Englert, E.H. Zackai, C. Naydenov, S. Hamamoto, R.W. Schekman, and J. Kim.  2011. Cranio-Lenticulo-Sutural Dysplasia associated with defects in collagen secretion. Clin. Genet. 80:169-176.

15. Kim, S.D., and Kim, J. 2008. Sequence analyses of presenilin mutations linked to familial Alzheimer’s disease. Cell Stress & Chaperones 13:401-412.

16. Kim, J., A. Thanabalasuriar, T. Chaworth-Musters, J.C. Fromme, E.A. Frey, P.I. Lario, P. Metalnikov, K. Rizg, N.A. Thomas, S.F. Lee. E.L. Hartland, P.R. Hardwidge, T. Pawson, N.C. Strynadka, B.B. Finlay, R. Schekman, and S. Gruenheid. 2007. The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.  Cell Host & Microbe 2:160-171.

17. Kim, J., B. Kleizen, R. Choy, G. Thinakaran, S.S. Sisodia, and R. Schekman. 2007. Biogenesis of g–secretase early in the secretory pathway. J. Cell Biol. 179:951-963.

18. Sun, C., S.L. Rusch, J. Kim, and D.A. Kendall. 2007. Chloroplast SecA and Escherichia coli SecA have distinct lipid and signal peptide preferences. J. Bacteriol. 189:1171-1175.]

19. Kim, J., S. Hamamoto, M. Ravazzola, L. Orci, and R. Schekman. 2005. Uncoupled  packaging of amyloid precursor protein and presenilin 1 into COPII vesicles. J. Biol. Chem. 280:7758-7768.

20. Kim, J., and Schekman, R. 2004. The ins and outs of presenilin 1 membrane topology.  Proc. Natl. Acad. Sci. USA 101:905-906.