Jonathan Paul M Mochel

DVM, MSc, PhD, Diplomate ECVPT
Professor
Biomedical Sciences
Vet Diagnostic & Production Animal Medicine
Veterinary Preventive Medicine Graduate Programs
515-294-7424
2448 Lloyd
ISU Directory Link

CV

Dr. Jon Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Alfort. He completed his Doctorate studying Neurosciences in collaboration with the College de France and received the Silver Medal from Paris XII for his work. Dr. Mochel holds a MS in Pharmacology and Pharmacokinetics and is a Diplomate of the European College of Veterinary Pharmacology and Toxicology (ECVPT). He completed his Ph.D at Leiden University, with a focus on the mathematical modeling of the renin-angiotensin system for cardiovascular diseases. He is a founder of the Animal Health Modeling & Simulation Society which aims at promoting the dissemination of mathematical modeling in Veterinary Sciences. Dr. Mochel is an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the ECVPT. He is a Fellow of the American Academy of Veterinary Pharmacology and Therapeutics and an ad hoc Study Section Reviewer for the US National Science Foundation, the UK Medical Research Council and the CNRS/INSERM ATIP-Avenir Program. He is currently the Vice-President of the European Association of Veterinary Pharmacology and Toxicology. His research pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental models and patients. He has authored more than 85 peer-reviewed publications in select biomedical journals and is the co-founder of LifEngine Animal Health, a Y Combinator company developing gene editing solutions for canine oncology, and 3D Health Solutions, a platform for efficient drug screening in pharmaceutical research.

Education & Certifications  
DEFV, Veterinary Medicine Degree, 2006, National Veterinary School of Toulouse, Toulouse (France)
MS, Pharmacology, 2006, Paul Sabatier University, Toulouse (France)
DVM, Veterinary Medicine, 2007, Alfort Veterinary School, Paris 12 Val de Marne University, Maisons-Alfort
MS, Clinical Pharmacology and Pharmacokinetics, 2009, Paul Sabatier University, Toulouse (France)
Resident, Veterinary Pharmacology and Toxicology (DECVPT), 2013, European College of Veterinary Pharmacology and Toxicology, Basel​
PhD, Quantitative Systems Pharmacology, 2015, Leiden University, Leiden (Netherlands)
 
Teaching  
Drug Metabolism
Pharmacokinetics
Basic Autonomic Anatomy and Physiology and Chemical Mediators
Cholinergic Transmission
Noradrenergic Transmission
5-HT and Pharmacology of Migraines and Purines
Local Hormones: Cytokines, Biologically Active Lipids and Peptides
Peptides and Nitric Oxide
Control of Blood Glucose and Diabetes Mellitus
Obesity
Pituitary and Adrenal Cortex
 
Professional Positions
2016-Present: Associate Professor (Presidential High-Impact), Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA
2015-2016: Quantitative Systems Pharmacology Leader, Roche Innovation Center, Pharma Research and Early Development, Basel
2013-2015: Senior Pharmacology Modeler, Department of Modeling and Simulation, Novartis, Basel
2011-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, St Johann Campus, Pharmacology Modeling and Simulation, Basel
2009-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, Centre de Recherche Sante Animale, DMPK and Safety, Saint-Aubin
2007-2008: Chief Intern, Veterinary Internal Medicine and Surgery, Small Animal Internal Medicine and Surgery, Alfort Veterinary School, Maisons-Alfort
2004-2006: Teaching Assistant, Department of Physiology and Therapeutics, National Veterinary School of Toulouse, Toulouse
 
Research Focus & Interests  
Clinical Pharmacology
Pharmacokinetics and Pharmacodynamic Modeling
Cardiovascular Research
Translational Medicine (One Health)
 
Honors & Awards  
2006 - Valedictorian, Veterinary Medicine Graduate Class, National Veterinary School of Toulouse
2007 - Silver Medal for Outstanding Veterinary Thesis, Alfort Veterinary School
2007 - Valedictorian, Veterinary Internal Medicine and Surgery Internship National Competitive Exam, French National Veterinary Schools
2008 - Valedictorian, Master of Sciences (M2), Paul Sabatier University
2013 - Diplomate, European College of Veterinary Pharmacology and Toxicology
2017 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
2017 - Fellow, American Academy of Veterinary Pharmacology and Therapeutics
2017 - Councilor, American Academy of Veterinary Pharmacology and Therapeutics
2017 - President, Animal Health Modeling and Simulation Society
2018 - President Elect, European Association of Veterinary Pharmacology and Therapeutics
2018 - Alumni, Y Combinator Seed Accelerator Program
2019 - Iowa State CVM Award for Early Career Achievement in Research
2020 - John Pappajohn Entrepreneurial Venture Competition Award (ranked #1/43)
2020 - Iowa State Exemplary Faculty Mentor Award
2020 - Iowa State University CVM International Service Award
2021 - IowaBio Biotechnology Association Award
2021 - Chair, Scientific Advisory Panel, Translational RAAS Interest Group
2021 - Inductee, Marquis Who’s Who Entrepreneurs in America 
2021 - Inductee, Marquis Who’s Who Top Doctors in America
2022 - Inductee, Sigma XI Scientific Research Honor Society
2022 - Chair, QSP Design of Innovative Combination Therapies for Complex Diseases, Leiden
2022 - American Academy of Veterinary Pharmacology and Therapeutics Research Award
2022 - Iowa State CVM Award for Mid-Career Achievement in Research  
 
Leadership/Committees/Council  
2015 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
2017 – President, Animal Health Modeling and Simulation Society
2017 – Fellow, American Academy of Veterinary Pharmacology and Therapeutics
2017 – Executive Board Member, American Academy of Veterinary Pharmacology and Therapeutics
2017 – Executive Board Member, European Federation for Pharmaceutical Sciences
 
2018 – President Elect, European Association of Veterinary Pharmacology and Toxicology
2018 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
2018 – Thrust Leader, National Institute of Antimicrobial Resistance and Education
2019 – Board Member, Translational Renin-Angiotensin-Aldosterone System Interest Group
2021 - Iowa State CVM Award for Mid-Career Achievement in Research
2022 - President Elect, TRIG
 
Memberships  
2017 – President, Animal Health Modeling and Simulation Society
2017 – Fellow, American Academy of Veterinary Pharmacology and Therapeutics
2017 – Executive Board Member, European Federation for Pharmaceutical Sciences
2017 – Member, International Society of Pharmacometrics
2017 – Member, American Association of Pharmaceutical Scientists
2017 – Member, American Gastroenterology Association
2017 – Member, Comparative Gastroenterology Society
2018 – President Elect, European Association of Veterinary Pharmacology and Toxicology
2018 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
2018 – Thrust Leader, National Institute of Antimicrobial Resistance and Education
2018 – Member, Clinical and Laboratory Standards Institute for Antimicrobial Susceptibility Testing
2019 – Board Member, Translational Renin-Angiotensin-Aldosterone System Interest Group
2021 – Platinum Member, American Association for the Advancement of Science
2021 – Marquis Who’s Who Entrepreneurs in America
2021 – Marquis Who’s Who Top Doctors in America
2022 – Full Member, Sigma XI Scientific Research Honor Society
 
Selected Publications  

1: Allenspach K, Borcherding DC, Iennarella-Servantez CA, Mosichuk AP, Atherly T, Sahoo DK, Kathrani A, Suchodolski JS, Bourgois-Mochel A, Serao MR, Serao NV, Willette A, Perez BA, Gabriel V, Mao S, Kilburn L, Dang V, Borts D, Almada LL, Fernandez-Zapico ME, Phillips GJ, Jergens AE, Mochel JP. Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials. Clin Transl Med. 2022 Sep;12(9):e1047. doi: 10.1002/ctm2.1047. PMID: 36149786; PMCID: PMC9506423.

2: Sahoo DK, Borcherding DC, Chandra L, Jergens AE, Atherly T, Bourgois-Mochel A, Ellinwood NM, Snella E, Severin AJ, Martin M, Allenspach K, Mochel JP. Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor. Cancers (Basel). 2022 Jul 20;14(14):3525. doi: 10.3390/cancers14143525. PMID: 35884586; PMCID: PMC9322748.

3: Kopper JJ, Iennarella-Servantez C, Jergens AE, Sahoo DK, Guillot E, Bourgois-Mochel A, Martinez MN, Allenspach K, Mochel JP. Harnessing the Biology of Canine Intestinal Organoids to Heighten Understanding of Inflammatory Bowel Disease Pathogenesis and Accelerate Drug Discovery: A One Health Approach. Front Toxicol. 2021 Nov 10;3:773953. doi: 10.3389/ftox.2021.773953. PMID: 35295115; PMCID: PMC8915821.

4: Martinez MN, Mochel JP, Neuhoff S, Pade D. Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics. AAPS J. 2021 Apr 27;23(3):59. doi: 10.1208/s12248-021-00590-0. PMID: 33907906.

5: Minkler S, Lucien F, Kimber MJ, Sahoo DK, Bourgois-Mochel A, Musser M, Johannes C, Frank I, Cheville J, Allenspach K, Mochel JP. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man's Trash Is Another Man's Treasure. Cancers (Basel). 2021 Jan 23;13(3):422. doi: 10.3390/cancers13030422. PMID: 33498666; PMCID: PMC7865365.

6: Sebbag L, Mochel JP. An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface. Med Res Rev. 2020 Nov;40(6):2566-2604. doi: 10.1002/med.21716. Epub 2020 Jul 31. PMID: 32735080.

7: Ambrosini YM, Park Y, Jergens AE, Shin W, Min S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP, Kim HJ. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions. PLoS One. 2020 Apr 17;15(4):e0231423. doi: 10.1371/journal.pone.0231423. PMID: 32302323; PMCID: PMC7164685.

8: Vaghi C, Rodallec A, Fanciullino R, Ciccolini J, Mochel JP, Mastri M, Poignard C, Ebos JML, Benzekry S. Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors. PLoS Comput Biol. 2020 Feb 25;16(2):e1007178. doi: 10.1371/journal.pcbi.1007178. PMID: 32097421; PMCID: PMC7059968.

9: Sebbag L, Allbaugh RA, Weaver A, Seo YJ, Mochel JP. Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics. Front Pharmacol. 2019 Jul 9;10:752. doi: 10.3389/fphar.2019.00752. PMID: 31354477; PMCID: PMC6629934.

10: Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun 18;11:130. doi: 10.3389/fnagi.2019.00130. PMID: 31275138; PMCID: PMC6591269.

Complete List of Published Work