Jonathan Paul M Mochel

DVM, MSc, PhD, Diplomate ECVPT

 

Dr. Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Toulouse. In 2007, he completed his Doctorate studying Neurosciences in collaboration with the College de France (Paris), and received the Silver Medal from the National Veterinary School of Alfort for his work.

During his veterinary undergraduate studies Dr. Mochel also obtained a Masters in Pharmacology and Pharmacokinetics (2006) from the University of Toulouse. Following a Medical Internship in Veterinary Medicine and Surgery at Maisons-Alfort (2006-2008), he also got a Master of Science (MS) in Pharmacology and Pharmacokinetics from the University of Toulouse. He then pursued a 4-year Specialization program in Pharmacology and Toxicology (European Board) and earned his title of European Specialist in Veterinary Pharmacology and Toxicology.

Dr. Mochel did his Ph.D at Leiden University under the supervision of Pr. Meindert Danhof, whose focus was on the modeling of the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs.

In 2012, he co-founded the Animal Health Modeling & Simulation (AHM&S) Society, together with Pr. Johan Gabrielsson (University of Agricultural Sciences, Uppsala, Sweden), and Pr. Jim Riviere (Kansas State University, USA), which aims at promoting the development, application, and dissemination of Modeling and Simulation techniques in the field of Veterinary Sciences (http://www.ahmss.com/).


Since joining Novartis Pharmaceuticals in 2013, he had been working as a Senior Pharmacology Modeler in the Modeling and Simulation (M&S) group formed by Dr. Donald Stanski. He thereafter operated as a Quantitative Pharmacology Leader in the Research M&S department of Dr. Thierry Lave at Roche.

Dr. Mochel is currently an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the European College of Pharmacology and Toxicology (http://www.ecvpt.org/).

His research, which falls under the scope of the One Health initiative, pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental (i.e rodent) models and patients.

Education & Certifications  
  • DEFV, Veterinary Medicine Degree, 2006, National Veterinary School of Toulouse, Toulouse
  • MS, Pharmacology, 2006, Paul Sabatier University, Toulouse
  • DVM, Veterinary Medicine, 2007, Alfort Veterinary School, Paris 12 Val de Marne University, Maisons-Alfort
  • MS, Pharmacology/Pharmacokinetics, 2009, Paul Sabatier University, Toulouse
  • Resident, Veterinary Pharmacology and Toxicology, 2013, European College of Veterinary Pharmacology and Toxicology, Basel​
  • PhD, Pharmacology, 2015, Leiden University, Leiden
Teaching  
  • Drug Metabolism
  • Pharmacokinetics
  • Basic Autonomic Anatomy and Physiology and Chemical Mediators
  • Cholinergic Transmission
  • Noradrenergic Transmission
  • 5-HT and Pharmacology of Migraines and Purines
  • Local Hormones: Cytokines, Biologically Active Lipids and Peptides
  • Peptides and Nitric Oxide
  • Control of Blood Glucose and Diabetes Mellitus
  • Obesity
  • Pituitary and Adrenal Cortex

Professional Positions

  • 2016-Present: Associate Professor (Presidential High-Impact), Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA
  • 2015-2016: Quantitative Systems Pharmacology Leader, Roche Innovation Center, Pharma Research and Early Development, Basel
  • 2013-2015: Senior Pharmacology Modeler, Department of Modeling and Simulation, Novartis, Basel
  • 2011-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, St Johann Campus, Pharmacology Modeling and Simulation, Basel
  • 2009-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, Centre de Recherche Sante Animale, DMPK and Safety, Saint-Aubin
  • 2007-2008: Chief Intern, Veterinary Internal Medicine and Surgery, Small Animal Internal Medicine and Surgery, Alfort Veterinary School, Maisons-Alfort
  • 2004-2006: Teaching Assistant, Department of Physiology and Therapeutics, National Veterinary School of Toulouse, Toulouse
Research Focus & Interests  
  • Clinical Pharmacology
  • Pharmacokinetics and Pharmacodynamic Modeling
  • Cardiovascular Research
  • Translational Medicine (One Health)
Honors & Awards  
  • 2006 - Valedictorian, Veterinary Medicine Graduate Class, National Veterinary School of Toulouse
  • 2007 - Silver Medal for Outstanding Veterinary Thesis, Alfort Veterinary School
  • 2007 - Valedictorian, Veterinary Internal Medicine and Surgery Internship National Competitive Exam, French National Veterinary Schools
  • 2008 - Valedictorian, Master of Sciences (M2), Paul Sabatier University
  • 2013 - Diplomate, European College of Veterinary Pharmacology and Toxicology
  • 2015 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
  • 2017 - Scientific Committee of the European Association of Veterinary Pharmacology and Toxicology Triennial, Poland
Memberships  
  • 2011 - Co-Founder, Animal Health Modeling and Simulation Society
  • 2013 - Diplomate, European Coll. of Veterinary Pharmacology and Toxicology
  • 2015 - Member, European Ass. for Veterinary Pharmacology and Toxicology
  • 2015 -Board member, European Federation for Pharmaceutical Sciences
  • 2015 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
  • 2016 - Fellow, American Academy of Vet. Pharmacology and Therapeutics
  • 2017 - Counselor, American Academy of Vet. Pharmacology and Therapeutics
  • 2017 - President, Animal Health Modeling and Simulation Society
  • 2017 - Member, International Society of Pharmacometrics
  • 2017 - Member, American Association of Pharmaceutical Scientists
  • 2017 - Member, American Gastroenterology Association
  • 2017 - Member, Comparative Gastroenterology Society
  • 2017 - NIH Study Section, Early Career Reviewer (ECR) Program
Selected Publications  
  1. Mochel JP, Tyden E, Hellmann K, Vendrig JC, Şenel S, Dencker L, Cristina RT, Linden H, Schmerold I. Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences. J Vet Pharmacol Ther. 2017 Dec 20. doi: 10.1111/jvp.12472. [Epub ahead of print] PubMed PMID: 29266320.
  2.  Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martín MG, Allenspach K. Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research. AAPS J. 2017 Dec 12;20(1):17. doi: 10.1208/s12248-017-0178-1. PubMed PMID: 29234895.
  3. Bon C, Toutain PL, Concordet D, Gehring R, Martin-Jimenez T, Smith J, Pelligand L, Martinez M, Whittem T, Riviere JE, Mochel JP. Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics. J Vet Pharmacol Ther. 2017 Dec 11. doi: 10.1111/jvp.12473. [Epub ahead of print] Review. PubMed PMID: 29226975.
  4. Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP. Model-Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative. CPT Pharmacometrics Syst Pharmacol. 2017 Nov 27. doi: 10.1002/psp4.12262. [Epub ahead of print] PubMed PMID: 29178333.
  5. Sebbag L, Harrington DM, Mochel JP. Tear fluid collection in dogs and cats using ophthalmic sponges. Vet Ophthalmol. 2017 Aug 27. doi: 10.1111/vop.12502. [Epub ahead of print] PubMed PMID: 28845579.
  6. Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple comparison procedure and modeling: a versatile tool for evaluating dose-response relationships in veterinary pharmacology - a case study with furosemide. J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. doi: 10.1111/jvp.12313. Epub 2016 May 11. PubMed PMID: 27166146.
  7. Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635. doi: 10.1002/psp4.12141. Epub 2016 Oct 22. PubMed PMID: 27770596; PubMed Central PMCID: PMC5193001.
  8. Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. doi: 10.1111/jvp.12311. Epub 2016 Apr 17. Review. PubMed PMID: 27086878.
  9. Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. doi: 10.1111/jvp.12278. Epub 2015 Nov 22.  Review. PubMed PMID: 26592724.
  10. Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. doi: 10.1007/s11095-014-1587-9. Epub 2014 Dec 2. PubMed PMID: 25446774.
  11. Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review. PubMed PMID: 26428686.
  12. Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs. Chronobiol Int. 2014 Jun;31(5):715-30. doi: 10.3109/07420528.2014.897711. Epub 2014 Mar 21. PubMed PMID: 24654920.
  13. Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. doi: 10.3109/07420528.2013.807275. Epub 2013 Aug 9. PubMed PMID: 23931032.
  14. Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel  JM. Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. doi: 10.1016/j.rvsc.2013.04.021. Epub 2013 May 31. PubMed PMID: 23726662.
  15. Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society: a new society promoting model-based  approaches in veterinary pharmacology. J Vet Pharmacol Ther. 2013 May 29. doi: 10.1111/jvp.12060. [Epub ahead of print] PubMed PMID: 23713757.
  16. Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B, Danhof M. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs. J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. doi: 10.1111/j.1365-2885.2012.01406.x. Epub 2012 May 8. PubMed PMID: 22568394.
  17. Gorden PJ, Ydstie JA, Kleinhenz MD, Brick TA, Smith JS, Griffith RW, Wulf LW, Rajewski SJ, Zhang M, Sidhu PK, Mochel JP, Coetzee JF. Comparative plasma and interstitial fluid pharmacokinetics and tissue disposition of ceftiofur crystalline free acid in cattle with induced coliform mastitis. In J Vet Pharmacol Ther. (In Press)

 
Abstracts and Conference Papers (Last four years)

  1. Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestinal Crypt Enteroids as a Research Model. International Society for Stem Cell Research Annual Meeting, Boston (2017).
  2. Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestine Crypt Enteroids as a Research Model. International Congress of Mucosal Immunology, Washington (2017).
  3. Balbas-Martinez V, Allenspach K, Kingsbury D, Jergens AE, Troconiz I, Mochel JP. One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network. 26th Population Approach Group in Europe (PAGE) Meeting, Budapest (2017).
  4. Smith JS, Mochel JP, Borts D, Haymond K, Schleining J, Coetzee JF. Pharmacokinetics of Fentanyl and Fentanyl Transdermal Patches in healthy and hospitalized Calves. American College of Veterinary Internal Medicine Forum, Washington (2017).
  5. Mochel JP. Modeling and Simulation: Shifting Gears to Accelerate Understanding of Variability in Animal and Translational Health. American Association of Veterinary Pharmacology and Therapeutics Biennial, Washington (2017).
  6. Kingsbury D, Fredericks J, Qi Y, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Watch It Grow. The Original Dog Mini-Gut. ISU College of Veterinary Medicine Winter Symposium, Ames (2017).
  7.  Vessieres F, Kingsbury D, Jergens AE, Procoli F, Logue CM, Nolan LK, Du Y, Mochel JP, Li G, Simpson KW, Allenspach K. Specific Virulence Factors in Mucosa-Associated E. coli of Dogs With Inflammatory Bowel Disease (IBD) Predict Survival. European College of Veterinary Internal Medicine Congress, Malta (2017).
  8. Allenspach K, Mochel JP, Du Y, Priestnall S, Moore F, Slaytor M, Rodrigues A, Day M, Ackermann M, Krockenberger M, Mansell J, WSAVA GI Standardization Working Group, Suchodolski J, Berghoff N, Jergens AE. Correlating Gastrointestinal Histopathologic Findings to Clinical Disease Activity in Dogs with Idiopathic Inflammatory Bowel Disease. European College of Veterinary Internal Medicine Congress, Malta (2017).
  9. Sebbag L, Harrington D, Mochel JP. Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges. American College of Veterinary Ophthalmology Conference, Baltimore (2017).
  10.  Mochel JP, Kingsbury D, Jergens AE, Allenspach K. Using Canine Intestinal Stem Cells to Advance Drug Development, Precision and Regenerative Medicine. ISU Faculty Research Symposium, Ames (2017)
  11. Smith JS, Zwueste D, Beahm A, Siegel K, Mochel JP, Winger K. Neurologic diseases of miniature companion pigs: 19 Cases (2000-2015). ISU Neuroscience Symposium, Ames (2017).
  12. Rowen NM, Mochel JP, Gannon M, Nelson M, LeVine DN. Regulation of Canine Neutrophil Extracellular Trap Formation by Immune-mediated Hemolytic Anemia Therapeutics. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
  13. Hepner P, Sebbag L, Allbaugh R, Showman L, Perera A, Strong T, Mochel JP, Wiggans T, Maggs D. Merial-NIH National Veterinary Scholars Symposium, Ames (2017).
  14. Slagel C, Smith JS, Mochel JP, Plummer P. Concurrent use of an immunostimulant and antibiotic improves treatment outcome in a sheep model of catheter associated urinary tract disease due to Pseudomonas aeruginosa. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
  15. McDowell W, Mochel JP, Showman L, Perera A, Hepner P, Sebbag L. Effect of tear collection method on total protein content and drug concentration in tear fluid of dogs and cats. NIH National Veterinary Scholars Symposium, Ames (2017).
  16.  Mochel J, Danhof M. Pharmacodynamics of the renin-angiotensin aldosterone system and blood pressure in relation to food intake in dogs. 25th Population Approach Group in Europe (PAGE) Meeting, Lisbon (2016).
  17.  Mochel J. Chronopharmacology of the renin-angiotensin network in dogs. The value of model-based approaches: some ‘food for thought’. International Seminar Programme on Drug Innovation, Utrecht (2016).
  18.  Mochel J, Seewald W, Danhof M. Pharmacokinetics of the angiotensin receptor-neprilysin inhibitor LCZ696 in furosemide-treated dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  19.  Mochel J, Peyrou M, Giraudel J, Danhof M. First-in-class angiotensin receptor-neprilysin inhibitor LCZ696 markedly influences the dynamics of circulating cGMP and biomarkers of the renin-angiotensin aldosterone system in dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  20. Mochel J. Chronopharmacology of the renin-angiotensin aldosterone system in dogs: the value of pharmacokinetic/pharmacodynamic modeling. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  21. Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel J. Model-based dose-response analysis of furosemide effect on the renin-angiotensin cascade and diuresis in dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  22. Pelligand L, Mochel J. Monte Carlo simulations and their application in veterinary medicine. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  23. Pelligand L, Soubret A, King JN, Elliot J, Mochel J. Simultaneous intravenous and subcutaneous population modelling of robenacoxib disposition kinetics in cats. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  24.  Mochel J, Bornkamp B, Bieth B. Evaluating the dose-response relationship of furosemide on diuresis and RAAS activation in dogs combining multiple comparisons and modeling techniques. 24th Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
  25.  Pelligand L, Renard D, Soubret A, King JN, Elliot J, Mochel J. Modeling of pharmacokinetic data using nonlinear mixed-effects: a paradigm shift in veterinary pharmacology. A case study with the nonsteroidal anti-inflammatory robenacoxib in cats. 24th Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
  26.  Mochel J, Burkey B, Fink M, Garcia R, Peyrou M, Giraudel J, Renard D, Danhof M. First-in-class angiotensin receptor neprilysin inhibitor LCZ696 modulates the dynamics of the renin cascade and natriuretic peptides system with significant reduction of aldosterone exposure. 63rd Annual Scientific Session of the American College of Cardiology, Washington (2014).
  27.  Mochel J, Renard D, Fink M, Danhof M. Daily variations of renin, urinary electrolytes and blood pressure are driven by food intake in dogs. 7th Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology, Noordwijkerhout (2014).
  28.  Fink M, Mochel J, Gabrielsson J, Collard W, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society (AHM&S): A new society promoting model-based approaches for a better integration and understanding of quantitative pharmacology in Veterinary Sciences. 22nd Population Approach Group in Europe (PAGE) Meeting, Glasgow (2013).
  29.  Mochel J, Fink M, Peyrou M, Desevaux C, Deurinck M, Danhof M. Chronobiology of the renin-angiotensin-aldosterone system in Dogs: relation to blood pressure and renal physiology. 22nd Population Approach Group in Europe (PAGE) Meeting, Glasgow (2013).
  30.  Mochel J. Tuning in to body’s rhythms to adapt dosing schedules. International Cardiology Advisory Board Meeting, Zurich (2013)