Vellareddy Anantharam

Research Associate Professor
1107 Vet Med
Education & Certifications  
  • BS, Chemistry, 1980, Bangalore University, INDIA
  • MS, Biochemistry, 1982, Bangalore University, INDIA
  • PhD, Molecular Biophysics, 1987, Indian Institute of Science, Bangalore, INDIA
  • Post-doc, Membrane-Cell Biology, 1990, Johns Hopkins Medical School 

  • 2006-Present                       Associate Professor (Affiliate), Biomedical Sciences, CVM, Iowa State Univ., Ames, IA

  • 2000-2006                          Adjunct Assistant Professor, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA

  • 1999                                   Assistant Specialist, Dept. of Community and Environmental Medicine, University of California, Irvine, CA

  • 1997-1999                          Senior Scientist, Drug Discovery Division, Axiom Biotechnologies Inc., San Diego, CA

  • 1995-1997                          Assistant Professor (Research), Dept. of Physiological Science, Univ. of California at Los Angeles, CA

  • 1990-1995                          Instructor, Neuroscience Program and Department of Pharmacology, University of Massachusetts Medical Center, Worcester, MA

  • 1987-1990                          Post-Doctoral Fellow, Dept. of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD
Research Focus & Interests  

The cellular and molecular mechanisms of neurodegeneration and the application of such information to the development of novel strategies for treating Parkinson's disease, Prion disease, and other neurodegenerative diseases.  

Research interests also include the role of oxidative stress and endoplasmic reticulum stress in etiopathogenesis of Parkinson's and Prion diseases.

PubMed link to Anantharam, V

Honors & Awards  
  • Johns Hopkins Medical School Physiology Fellowship Award (1987 - 1990)
  • Employee of the Year Award, Axiom Biotechnologies Inc. (now Sequenom Inc) (1999)
  • Iowa Technology Commercialization Fellow, Iowa State University (2008)
  1. Society for Neuroscience
  2. American Society for Cell Biology
  3. International Brain Research Organization
  4. Society for Toxicology
  5. Central States Society of Toxicology
  6. International Society of Neurotoxicology
  7. American Society for Transplantation
Selected Publications

  1. Thompson KT, Anantharam V, Behrstock S, Bongarzone E, Campagnoni AT and Tobin AJ (2000) Conditionally Immortalized Cell Lines, Engineered to Produce and Release GABA Modulate the Development of Behavioral Seizures. Experimental Neurology, 161: 481-489. PMID: 10686070.
  2. Zhang D, Anantharam V, Kanthasamy A, and Kanthasamy AG (2007) Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J Pharmacol Exp Ther 322:913-922. PMID: 17565007
  3. Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG (2016) Mitoapocynin treatment protects against neuroinflammation and dopaminergic neurodegeneration in a preclinical animal model of Parkinson's disease. J Neuroimmune Pharmacol. 11(2):259-78.  PMCID: PMC4995106
  4. Brenza TM, Ghaisas S, Ramirez JE, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B (2016) Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. Nanomedicine. Oct 19. pii: S1549-9634(16)30174-5. doi:10.1016/j.nano.2016.10.004. [Epub ahead of print]. PMC Journal - In Process
  5. Anantharam V, Kitazawa M, Wagner J, Kaul S, and Kanthasamy AG (2002) Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22:1738-1751. PMID: 11880503
  6. Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, and Kanthasamy AG (2003) Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur J Neurosci 18:1387-1401. PMID: 14511319
  7. Kitazawa M, Anantharam V, and Kanthasamy AG (2003) Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase C delta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 119:945-964. PMID: 12831855
  8. Jin H, Kanthasamy A, Anantharam V, Rana A, and Kanthasamy AG (2011) Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. J Biol Chem 286:19840-19859. PMCID: PMC3103361
  9. Asaithambi A, Kanthasamy A, Saminathan H, Anantharam V, and Kanthasamy AG (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6:43. PMCID: PMC3145571
  10. Saminathan H, Asaithambi A, Anantharam V, Kanthasamy AG, and Kanthasamy A (2011) Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCdelta-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology 32:567-577. PMCID: PMC3328137
  11. Asaithambi A, Ay M, Jin H, Gosh A, Anantharam V, Kanthasamy A, and Kanthasamy AG (2014) Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PLoS One 9:e96947. PMCID: PMC4013052
  12. Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG (2014) Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. J Biol Chem. 289(50):34743-67. PMCID: PMC4263877
  13. Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, and Kanthasamy AG (2005) Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J Pharmacol Exp Ther 315:69-79. PMID: 15987830
  14. Choi CJ, Anantharam V, Saetveit NJ, Houk RS, Kanthasamy A, and Kanthasamy AG (2007) Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicol Sci 98:495-509. PMCID: PMC3407037
  15. Choi CJ, Anantharam V, Martin DP, Nicholson EM, Richt JA, Kanthasamy A, and Kanthasamy AG (2010) Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease. Toxicol Sci 115:535-546. PMCID: PMC2871751
  16. Kim DS, Jin H, Anantharam V, Gordon R, Kanthasamy A, Kanthasamy AG (2016) p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity. Neurotoxicology Apr 20. pii: S0161-813X(16)30057-2. doi: 10.1016/j.neuro.2016.04.012. PMCID: PMC5073055